[治疗]□环磷酰胺（Cyclophospham ide）□

结果显示，畸形主要表现颌面部畸形、趾（指）缺乏、冠状动脉缺陷、脐疝、血管瘤、闭肛、直肠阴道瘘及腭裂等。结果1例出现自发性流产，1例宫内死胎，1例出生2天后死亡。环磷酰胺的致畸作用主要发生在妊娠头3个月用药，尚未见妊娠中、后期用药引起胎儿畸形的报道。结果显示在出生后随访的42个月内，未见婴儿出现任何发育异常。一次性静脉注射500mg 的药物，药物在母乳中存在可长达6小时。个案报道显示，哺乳妇女每周注射环磷酰胺800mg，共6周，婴儿在停止哺乳后9天出现粒细胞减少，副作用持续达12天。 ［1］Enns GM，Roeder E，Chan RT，et al.Apparent cyclophosphamide（Cy toxan）embryopathy：A distinct phenotype？Am J Med Genet.1999；86∶237-241 ［2］Giacalone PL，Laf argue F，Benos P.Chemotherapy for breast carcinoma during pregnancy.Cancer.1999；86∶2266-2272 ［3］Nicholson HO.Cytotoxic drugs in pregnancy：review of reported cases.J obstet Gynaecol Br commonw.1968；75∶307-312 ［4］Dutodola JI.Administration of cyclophosphamide during late pregnancy and early lactation：a case report.J Natl Med Assoc.1979；71∶165-166 ［5］Wiernik PH，Duncan JH.Cyslophosphamide in human milk.Lancet 1971；1∶912 ［6］Amato D，Niblet JS.Neutropenia from cyclophosphamide in breast milk. Med J Aust.1977；1∶383-384 ［7］Okun DB，Groncy PK，Sieger L，et al.Acute leukaemia in pregnancy：transient neonatal myel suppression after combination chemotherapy in the mother.Med Pediatr Oncol.1979；7∶315-319